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Dr. Prathapan Sreedharan

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Dr. Prathapan Sreedharan
Reader in Organic Chemistry
Department of Applied Chemistry
CUSAT.
Ph.      +919846142512
         
Ph.D. in Organic Chemistry (1988) from IIT Kanpur, under the supervision of Professor M. V. George
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Tenures

  • Assistant Instructor, Carnegie Mellon University, Pittsburgh, USA. (1991 to 1994)
  • Norman and Rosita Winston Fellow, The Rockefeller University, New York, USA. (1998 to 1991)
  • Lecturer, CUSAT(1994-2003)
  • Reader, CUSAT (2003-2007).
  • Associate professor CUSAT. (2007-date)

AREAS OF SPECIALISATION

Synthetic and Mechanistic Organic Chemistry, Photochemistry, Electron Transfer Reactions, Porphyrin Chemistry.

MAJOR AREAS OF RESEARCH

  • Synthesis and transformations of various heterocycles.
  • Synthesis of spiro and dispiro compounds.
  • Synthesis of tricyclics.
  • Synthesis of facially-encumbered porphyrins.
  • Development of novel reagents for the stereoselective dehydration, dehydrogenation and oxidation under mild conditions.
  • Extensive Investigation on Cycloaddition reactions (1,3-Dipolar & Diels-Alder)
  • Photophysical and photochemical studies of bischromophoroic systems

VISITING FELLOWSHIPS AND POSTDOCTORAL TRAINING

  • January ‘04 - January ’05: Visiting Fellow Carnegie Mellon University, Pittsburgh, U.S.A.
  • July 2000 - November ’01: Visiting fellow, North Carolina State University, Raleigh, USA.
  • May ’99 - July ’99: Visiting Fellow, University of Connecticut, U.S.A.
  • June’98 - November ’98: Visiting Fellow, North Carolina State University, Raleigh, USA.
  • August ’91- September’93: Postdoctoral Fellow, Carnegie Mellon University, Pittsburgh, U.S.A.
  • March’88-August ’91: Norman and Rosita Winston Fellow, The Rockefeller University, New York, U.S.A.

Membership of Professional Societies

  • Member: Editorial Board of International Journal of Chemistry (published from Canada)
  • Member : Editorial Board of International Journal of Applied Chemistry and Chemical Engineering(published from Europe)
  • Reviewed articles submitted to several international journals
  • Permanent Member, Chemical Research Society of India

Membership in Academic /University bodies

  • Member: Board of Studies, Cochin University of Science and Technology
  • Member: PG Board (Chemistry), Kerala University
  • Member: Academic Council, CUSAT (2012 to 2014)
  • Member: University Senate, CUSAT (2012-2014).
  • Member: Faculty of Science, CUSAT (2012 to date).
  • Member: Program Implementation Group for PURSE fund allocation totaling Rs. 50000000 (five crores), CUSAT
  • Chairman: Council of Wardens, CUSAT (in charge of 10 hostels run by the University) 2010-2014
  • Member : Advisory Committee for Coaching Schemes for SC/ST/OBC/Minority Students
  • Member: Advisory Committee on activities of Department of Youth Welfare
  • President: Alumni Association, Department of Applied Chemistry, CUSAT.
  • Executive :Member, Parent Teacher Association, Department of Applied Chemistry, CUSAT

Organization of seminar /symposia

  • Invited and Endowment Lectures at various Colleges, Universities and Institutions (23)
  • Coordinator: International Conference, MATCON 2010 at CUSAT
  • Coordinated several programs for College teachers and School Students, CUSAT
  • Member: National Advisory Board for National and International Seminars (9)

TEACHING EXPERIENCE

  • January 1984 to May 1986: Teachin Assistant, Department of Chemistry, IIT Kanpur.
  • August 2001 to December 2002: Assistant Instructor, Department of Chemistry, Carnegie Mellon University, Pittsburgh, U.S.A.
  • April 11994 to date: Department of Applied Chemistry, Cochin University of Science and Technology, India

Courses

  • MSc Chemistry; CHE 2204 Organic Chemistry, CHE2206 Organic Spectroscopy,
  • M.Phil. Chemsity: CHE4102 Modern methods in Chemistry

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RESEARCH PROJECTS

  1. Synthesis and Applications of Novel Cyclic Burgess Reagent Analogues.”- CSIR-funded research project (Completed in 2004).
  2. “Synthesis and transformations of phenanthrenone-9-ylidene ketones.”- DST- funded research project (completed in 2005).
  3. “Investigations on controlling the selectivity of photochemical transformations.”- DRDO- supported research project (Completed in 2006).
  4. “An Improved Method for the Synthesis of Nitriles with PEG-Supported Burgess Reagent.”- CSIR- aided research project (Co-Investigator, completed).
  5. Studies on Photocatalyis by nano titania in pollution control – BRNS supported research (Co-investigator, completed).
  6. Development of anti-WSSV drugs from mangrove plants endemic to Indian coastal zone – DBT supported research project (Co-Investigator, completed).
  7. DBT sponsored project entitled “Microbial whole cells-metal combo mediated one pot method for the dynamic kinetic resolution of racemic epoxides” – Completed, Co-PI
  8. Kerala Government sponsored Ayurveda Project Title: Chemical Analysis and Standardization of Ayurvedic Formulations. – Completed, Co-PI
  9. Title of DST SERB project entitled: “Synthesis of new light emitting polymers and fabrication of polymer LEDs with desired characteristics” – ongoing , Co-PI

PATENTS

  • "Methods and intermediates for the synthesis of dipyrrin-substituted porphyrinic macrocycles," U.S. Patent Application No. 10/456, 321 .
  • “Regioisomerically pure oxochlorins and methods of synthesis,” U.S. Patent No. 6765092.

Ph. D. Thesis 

Ongoing - 5

Completed - 11

  1. Studies on the synthesis and transformations of a few Dibenzoylalkene type systems, Binoy Jose.
  2. Studies on the synthesis and transformations of a few bicyclic and dispiro compounds, Jean John Vadakkan.
  3. Studies on the synthesis and transformations of a few 2(3H)- and 3(2H) furanones, Vidya Raman.
  4. 2(3H) furanones and related substrates : Synthetic strategies and selectivity profile in their reactivity, Roshni, K. Thumpakara.
  5. Studies on the solvent dependence in the reaction of a few Anthracen-9-yl) Methyl Amines and Sulfanes with reactive acetylenes, Rekha R. Mallia.
  6. Synthesis and Photochemistry of a few olefin appended Dibenzobarralenes and Bisdibenzobarralenes, Ambily Mary Jacob.
  7. Blue, Green and orange-red light emitting polymers: Synthesis, charecterisation and prospects of applications in optoelectronic devices, Vidya G.
  8. Ground and excited state electron transfer reactions between a few Anthracene appended tertiary amines and suitable electron acceptors, Jomon P. Jacob.
  9. Studies on developing a facile route for the synthesis of highly substitutd quinolone and indole derivatives, Sandhya R.
  10. Investigations on electron transfer reactions of a few anthracene methyl sulfides with suitable electron acceptors and realated studies, Reshma G.
  11. Nucleophilic addition of nitrones to electron deficient acetylenes and related studies, Rakesh N.

A FEW SELECTED PUBLICATIONS (Since 2005)

  1. Synthesis of 3,3-dmethoxy-2-aryl-2,3-dihydro-1-oxa-cyclopenta[l]phenanthren-2-ols and their conversion to 2(3H)- and 3(2H)-Furanones, Jacob, A. M.; Thumpakkara, R. K.; Prathapan, S.; Jose, B. Tetrahedron 2005, 61, 4601.
  2. A novel electron transfer mediated reaction leading to lepidopterene, Vadakkan, J. J.; Mallia, R. R.; Prathapan, S.; Rath, N. P.; Unnikrishnan, P. A. Tetrahedron Lett. 2005, 46, 5918.
  3. Simple, efficient, and stereoselective oxidation of triphenylfurans to cis-but-2-ene-1,4-diones, Rappai, J. P.; Prathapan S.; Vishnu Unni, M. V.; and Unnikrishnan P. A. Synth. Commun. 2007, 37, 569.
  4. Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones, Rappai, J. P.; Raman, V.; Unnikrishna, P. A.; Prathapan, S.; Thomas, S. K.; Paulose, C. S. Bioorg. Med. Chem.Lett. 2009, 19, 764.
  5. Effect of a Strategically Positioned Methoxy Substituent on the Photochemistry of 3-Aryl-3H-1-Oxacyclopenta[l]Phenanthren-2-ones, Thumpakara, R. K.; Jose, B.; Unnikrishna, P. A.; Prathapan, S.; Rath, N. P. Org. Chem. Int. 2010. (doi:10.1155/2010/764185).
  6. A simple and efficient one-pot synthesis of nitriles from amides and oximes using in situ generated Burgess-type reagent, Rappai, J. P.; Karthikeyan, J.; Prathapan, S.; Unnikrishnan, P. A. Synth. Commun. 2011, 41, 2601.
  7. 8-Phenyl-16-thiapentacyclo [6.6.5.0 1,18 .0 2,7 .0 9,14 ]nonadeca- 2,4,6,9,11,13,18-heptaene, E. M. Mathew, M. Sithambaresan, P. A. Unnikrishnan and M. R. Prathapachandra Kurup, Acta Cryst. 2013, E69, o1165.
  8. (2E,7E )-2,7-Bis[(thiophen-2-yl)methylidene]cycloheptanone, C. Nithya, M. Sithambaresan, S. Prathapan and M. R. Prathapachandra Kurup, 2014, E70, o722.
  9. Dramatic solvent and concentration dependence in the reaction of (anthracen-9-yl)methanamines with suitable electron deficient acetylenes, Jomon P. Jacob, Reshma Gopalakrishnan, Rekha R. Mallia, Jean John Vadakkan, Perupparampil A. Unnikrishnan, Sreedharan Prathapan, J. Phys. Org. Chem. 2014, 27, 884-891.
  10. Domino reaction sequences leading to the formation of 2:2 adducts between acenaphthenequinone and acetophenone, Jomon P. Jacob, Christy Kunjachan, L. U. Sajitha, Roshini K. Thumpakara, K. Rakesh, V. Nidhisha, Perupparampil A. Unnikrishnan, Sreedharan Prathapan, ARKIVOC 2014, vi, 127-138.
  11. Facile one-pot method for the synthesis of arylmethanamines, J. P. Jacob, L. M. Lalu, R. Gopalakrishnan, R. R. Mallia, S. Prathapan, P. A. Unnikrishnan, J. Adv. Res. App. Che. & Che. Eng. 2014.
  12. Novel Burgess reagent mediated C-to-N aryl migration reaction in nitrones, T. S. Sajitha, S. Prathapan and P. A. Unnikrishnan, RSC Adv., 2014, 4, 44689–44691
  13. Efficient one-pot synthesis of (anthracen-9-yl)methyl sulfane derivatives, Reshma Gopalakrishnan, Jomon P. Jacob, Ranjith Chirakandathil, Perupparampil A. Unnikrishnan, Sreedharan Prathapan, Cogent Chemistry 2015, 1, 1033820.
  14. Studies on the solvent dependence in the reaction of (anthracen-9-yl)methyl sulfides with suitable electron deficient acetylenes, Reshma Gopalakrishnan, Jomon P. Jacob, Rekha R. Mallia, Perupparampil A. Unnikrishnan, Sreedharan Prathapan, J. Phys. Org. Chem. 2015, 28, 472.
  15. Diverse reactivity of nitrones towards electron deficient acetylenes, Sandhya Radhamani, Rakesh Natarajan, Peruparampil A. Unnikrishnan, Sreedharan Prathapan and John P. Rappai, New J. Chem. 2015, 39, 5580.
  16. Anthracen-9-yl)methyl sulfides as a mechanistic probe for chemical as well as photochemical electron-transfer reactions, Reshma Gopalakrishnan, Jomon P. Jacob, Sa ada Farhana T. Moideen, Ligi M. Lalu, Perupparampil A. Unnikrishnan, and Sreedharan Prathapan*., ARKIVOC, 2015.
  17. Ground and excited-state electron-transfer reactions of a few (anthracen-9-yl)methanamines: A comparative study, Jomon P. Jacob, Ligi M. Lalu, Reshma Gopalakrishnan, Rekha R. Mallia, Perupparampil A. Unnikrishnan, and Sreedharan Prathapan*., ARKIVOC, 2015
  18. A New Method for the Synthesis of 3-Substituted Indoles, Rakesh Natarajan · John P. Rappai · Peruparampil A. Unnikrishnan · Sandhya Radhamani · Sreedharan Prathapan, synlett., 2015.
  19. Metal-free synthesis of highly substituted quinolines under mild conditions, Rakesh Natarajan, Peruparambil A. Unnikrishnan, Sandhya Radhamani b, John P. Rappai, Sreedharan Prathapan., Tetrahedron Lett., 2016.